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Mixedemul a fost descris de Curling n W. Guli niar n Victor Horsley a constatat experimental pe mai- tiroidectomia duce la depresiunea nervoase a conside- rat tiroida o Mixedemul posttiroidectomie constatat de chirurgi care practicau tiroidectomia a fost explicat de Jacques Louis Reverdin n numit de Kocher n "casexie postoperatorie". Redmayne Murray n a folosit pentru prima extract injectabil al glandei tiroide pentru a trata un pacient cu mixedem a concluzionat timida este o cu secretie n Oswald a izoleze tiroglobulina, prezentnd-o ca o a tiroidei, iar nBaumann a stabilit dintre metabolismul iodului n Nicolae Paulescu, n colaborare cu A. Raymir, experimental o una nDubois, Benedict Harris au introdus n proba metabolismului bazal.

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Cardiovascular diseases lead to one third of the deaths worldwide, surpassing the mortality rate produced by neoplasia, acute respiratory failure and diabetes mellitus all together. In the world, approximately 17 million die annually because of cardiovascular disease and every 5 seconds one is suffering from a myocardial infarction. At the beginning only small parts of the patients were transferred to the hospital in charge for STEMI, so, we chose to study patients from the second year of the program and from last year. We made a retrospective study, including patients with STEMI that reached our hospital for primary angioplasty in the first 12h after the debut of the symptoms, aiming to make a parallel between the in-hospital mortality rates at maximum one month after the primary PCI.