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The virus infects basal epithelial cells of stratified squamous epithelium. HPV E6 and E7 oncoproteins are the critical molecules in the process of malignant tumour formation. Interacting with various cellular proteins, E6 and E7 influence fundamental cellular functions like cell cycle regulation, telomere maintenance, susceptibility to apoptosis, intercellular adhesion and regulation of immune responses. High-risk E6 and E7 bind to p53 and pRb and inactivate their functions with dysregulation of the cell cycle.

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На неопределенной глубине, едва видимая, простерлась чудовищных размеров карта -- сложнейшая сеть линий на ней сходилась точно в колонне центральной шахты. Некоторое время они смотрели на все это молча.

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Вот тут еще можно было узнать секцию массивной стены. Там -- пара изъеденных временем пилонов отмечали место, которое когда-то было позицией грандиозных ворот.

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