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More recent studies however show that HPV human papilloma virus infection is, perhaps, the most important factor, increasing cancer risk 32 times, compared to a mere 3 and 2. According to studies by M. Gillison, there are two head and neck cancer inducing methods: one through carcinogenetic effects cancer inducing effects of alcohol and smoking and the second through genomic instability caused by HPV, a sexually transmitted disease.

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HPV reprezintă un grup de peste de virusuri înrudite, dintre care peste 40 sunt răspândite prin contact sexual direct. Acestea sunt clasificate în grupuri cu risc scăzut şi grupuri cu risc înalt, în funcţie de potenţialul oncogenic.

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