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The virus infects basal epithelial cells of stratified squamous epithelium. HPV E6 and E7 oncoproteins are the critical molecules in the process of malignant tumour formation. Interacting with various cellular proteins, E6 and E7 influence fundamental cellular functions like cell cycle regulation, telomere maintenance, susceptibility to apoptosis, intercellular adhesion and regulation of immune responses. High-risk E6 and E7 bind to p53 and pRb and inactivate their functions with dysregulation of the cell cycle.

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Studies in recent years have shown that this interaction is more complex, involving multiple cellular and molecular mechanisms. Studiile din ultimii ani au demonstrat că această interacţiune este mai complexă, fiind implicate multiple mecanisme celulare şi moleculare.

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Just wanted to share my personal experience with cervical dysplasia and hpv, and hopefully I can help create awareness about the importance of early detection and regular pap smears. I know that this is still a topic not openly discussed because of the stigma of the disease, but I hope from this thread I can reach out to other women out there with symptoms but are scared to get a thorough check-up. In during one of my routine pap smears when we were trying to get pregnant, my OB-GYN felt a precancerous cells no hpv, tiny lentil-sized lump in my cervix.

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Он тихо подозвал существо; невероятно длинный язык лизнул ему руку. Мгновением позже могучее тело нежно потерлось о него и беззвучно удалилось.