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Numeroasele studii efectuate au aratat ca mutatiile genelor BRCA1 si BRCA2 care afecteaza linia germinala sunt responsabile de marea majoritate a cancerelor ereditare de san cancer pancreas genetique ovar1;7. Desi persoanele cu HBOC mostenesc o alela BRCA1 sau BRCA2 defectuoasa cancer pancreas genetique la unul dintre parinti, acestia prezinta o a doua alela functionala; in cazul in care si cea de-a doua alela devine nefunctionala  se dezvolta procesul neoplazic, prin acumularea de mutatii aditionale. Aceste tipuri de mutatii au fost identificate predominant la evreii Ashkenazi din Europa de Estcanadienii francezi si la islandezi1. Proteina BRCA1 este o fosfoproteina nucleara cu rol important in mentinerea stabilitatii genomice si in supresia tumorala; impreuna cu alte proteine supresoare ale tumorilor sau cu rol in transmiterea semnalului celular, formeaza un complex cu subunitati multiple  denumit BASC BRCA1-asociated genome surveillance complex ; de asemenea se asociaza cu ARN polimeraza II intervenind astfel in transcriptie, repararea ADN-lui dublu catenar, precum si in recombinare.

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Herceptin este administrat în tratamentul cancerului de sân. Dans le traitement du cancer du sein métastatique, Herceptin administré une fois par semaine a été étudié dans quatre études principales. În cazul cancerului de sân metastatic, Herceptin a fost studiat în patru studii principale. Excessive d'alcool, tabagisme, manque d'exercice et l'obésité?