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Both groups were observed for years by surveillance colonoscopy and by questionnaire. Because of the central role of transcription factor nuclear factor-κB NF-κB in pancreatic cancer, we investigated the roles of NF-κB in apigenin-induced growth inhibition in pancreatic cancer cells. It showed that apigenin reduced cell growth and induced apoptosis in the cells. Moreover, IKK blockage potentiated the anticancer efficacy of apigenin and IKK-β overexpression attenuated the apigenin-induced cell growth inhibition.
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