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The biologic behavior of squamous cervical carcinoma after hpv cancer progression therapy NAT according to immunohistochemical expression of E-cadherin and CD44v6 Mihaela Madalina Gavrilescu, Raluca Balan, Viorel Scripcariu, Dan Ferariu, Ludmila Lozneanu, Diana Popovici, Cornelia Amalinei Abstract The efficiency of neoadjuvant therapy in cervical carcinoma has been well demonstrated, although the cellular mechanisms of different response to this treatment have not been thoroughly investigated. The aim of our study was to assess the correlations between the alterations in E-cadherin and CD44v6 immunoexpression in cervical carcinoma, as a tool of evaluation the response to neoadjuvant therapy and its prognostic significance. The intensity of CD44v6 immunoexpression was higher in more aggressive tumors and E-cadherin immunoexpression was approximately constant among the cases with neoadjuvant therapy.

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This is one of the most common sexually transmitted infections, with a tropism for tissues such as squamous or mucosal epithelium. Human papillomavirus can be classified according to the ability of oncogenesis in low-risk genotypes, associated primarily with genital warts and high-risk, associated with premalignant and malignant lesions.

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The virus infects basal epithelial cells of stratified squamous epithelium. HPV E6 and E7 oncoproteins are the critical molecules in the process of malignant tumour formation.

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Если вы отпустите меня, для вас это не будет иметь значения. - Это не мое решение, - пояснила Серанис, - и ты недооцениваешь силу рассудка, если думаешь, что барьеры, удерживающие твой народ в городе, непробиваемы. Впрочем, мы не хотим удерживать тебя здесь насильно, но если ты вернешься в Диаспар, мы должны будем стереть все воспоминания о Лисе из твоего сознания.

- Она на миг заколебалась.

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Впрочем, оставим. Был ли запрет встроен Это исключало одну из возможностей. Ведь строители куполов вполне могли быть теми, кто изготовил робота и включил это табу в первичные инструкции машины. - Когда ты получил приказ.

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Кто его знает, возможно, и есть пути, которые ведут зз пределы города, но я не думаю, что по ним можно уйти далеко, даже если ты их и обнаружишь. Но пусть тебе даже и удастся эта попытка -- что толку. Твое тело не сможет долго продержаться в пустыне, где город уже будет не в состоянии защищать и кормить .

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