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Pentru majoritatea oamenilor, virusul papilomavirus uman HPV dispare de la sine, în mod spontan. Dar pentru alții care nu elimină virusul, anumite tipuri de HPV pot provoca cancere cervicale, vaginale și vulvare la femei și cancer anal la bărbați și femei.

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The virus infects basal epithelial cells of stratified squamous epithelium. HPV E6 and E7 oncoproteins are the critical molecules in the process of malignant tumour formation. Interacting with various cellular proteins, E6 and E7 influence fundamental cellular functions like cell cycle regulation, telomere maintenance, susceptibility to apoptosis, intercellular adhesion and regulation of immune responses. High-risk E6 and E7 bind to p53 and pRb and inactivate their functions with dysregulation of the cell human papillomavirus linked to cancer.

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