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My main current research area concerns the biologically-optimized and adapted radiotherapy with respect to the adverse tumour response phenotypes as well as the quality of radiation, irradiation technique and fractionation regime. Research description PROJECT 1 - Biologically Optimised Adaptive RT Aim: To combine the advantages of intensity modulated radiotherapy for photons, protons and light ions and molecular and functional imaging in order to exploit the potential to target precisely the adverse factors in the rectal cancer in brachytherapy and thus to tailor the treatment to the individual needs of the patients by developing quantitative methods for incorporating biological and functional information on adverse outcome treatment factors into the treatment planning and optimisation rectal cancer in brachytherapy and the implementation of the computational models and algorithms for dose prescription and treatment adaptation in the clinical treatment planning system. PROJECT 2 — Stereotactic Radiation Therapy — key factors and novel approaches Aim: To analyse and quantify a multiobserver variability of target and organs at risk delineation and to evaluate the clinical potential impact of the differences for radiosurgery. To analyse of the impact of the fractionation schedule in which the prescribed dose is delivered in Stereotactic Body Radiation Therapy SBRT on the tumour control probability for NSCLC depending on the intrinsic sensitivity of the cells to radiation and the oxygenation of the tumour and to explore the possibilities for the clinical validation of the theoretical findings.

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Spitalul Clinic Prof. Radioterapia s-a dovedit a fi o arm util n combaterea neoplaziilor. Cancerul de prostat este una dintre principalele cauze de mortalitate i morbiditate la nivel global, n rndul populaiei masculine.

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The equivalent dose rate of natural radionuclides in building materials has been measured and its change has been evaluated. The specific activities of natural radionuclides contained in building structures have been spectrometrically measured. The activity index and radium equivalent activity allowing to evaluate appropriateness of each material for such buildings from the point of radiation safety, have been determined.

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