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In Romania, the incidence of CRC in is We reviewed a series of studies that are related to colon cancer and studied the epithelial-mesenchymal transition at the front of tumor invasion EMT. Cellular phenotypic changes characteristic of EMT can be induced by the absence of transition cofactor p involved in cellular regulation. Loss of syndecan-1 marker is associated with local tumor stage and metastasis.

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Although the causes of this disease are not entirely understood, it is known that several factors influence its occurrence. Risk factors for colorectal cancer include age, family history of colon polyps, inflammatory bowel disease and hereditary syndromes, smoking, obesity, sedentarism, alcohol consumption. Evidence is mounting that detecting this risk factors is a eficient way of selecting persons at high risk for colon cancer, that should undergo the screening mesures. Key words: colon cancer, risk factors, colon polyps, inflammatory bowel disease, smoking, obesity, sedentarism, alcohol consumption.

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We also genotyped females and 62 males, who formed the control group. Genotyping results were related to environmental risk factors, smoking habit and diet. A significantly increased risk for CRC was observed in females and males with high daily fried red meat intake, carriers of the ArgGln OR 2.

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