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Un alt motiv important a fost nencrederea general ntr-un sistem de sntate total ineficient, motiv pentru care mamele au declarat c ar solicita informaii clare i amnunite cu privire la vaccin HPV i eficacitatea lui de la furnizorii de servicii medicale, pentru a fi motivate s-l accepte pentru fiicele lor [14]. Nivelurile de anticorpi anti-HPV au rmas un nivel crescut n grupul vaccinat, comparativ cu grupul placebo [17]. In mai multe studii au fost evaluate sigurana i tolerabilitatea vaccinurilor anti-HPV, unde simptomele locale i sistemice legate de injectare au fost, n general, uoare. Efectele adverse cele mai frecvent raportate au fost reacii la locul injectrii, descrise n recombinant human papillomavirus (hpv) quadrivalent vaccine ca durere, tumefiere sau eritem, similare de altfel cu efectele adverse ntlnite la administrarea vaccinurilor obinuite, incluse n planurile de vaccinare [19, 20].

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